Twice-Yearly Sunlenca Works Well for Initial HIV Treatment
From Poz Magazine online…
Sunlenca (lenacapavir), a long-acting injectable medication recently approved for treatment-experienced people with multidrug-resistant HIV, also works well for people starting antiretroviral therapy for the first time.
Results from the CALIBRATE trial showed that around 90% of study participants who used Sunlenca—either as daily pills or injections every six months—in combination with other antiretrovirals achieved an undetectable viral load.
Gilead Sciences’ Sunlenca (formerly GS-6207), the first approved HIV capsid inhibitor, disrupts the cone-shaped shell that surrounds the viral genetic material and essential enzymes. Laboratory studies showed that it interferes with multiple steps of the HIV life cycle. Because it works differently than existing antiretrovirals, it remains active against HIV that has developed resistance to other drugs. Sunlenca has a long half-life in the body, allowing it to be administered just once every six months.